Publications
-
Improving MRI-based dosimetry for holmium-166 transarterial radioembolization using a nonrigid image registration for voxelwise ΔR*2 calculation
M.W.M. van Wijk, L.E.L. Westlund Gotby, M.J. Arntz, M.J.R. Janssen, D. Lobeek, G.H. van de Maat, C.G. Overduin, J.F.W. Nijsen Background: Transarterial radioembolization (TARE) is a treatment modality for liver tumors during which radioactive...
-
Intratumoral injection of holmium-166 microspheres as neoadjuvant therapy of soft tissue sarcomas in dogs
N.C. Mosink, J.F.W. Nijsen, G.C.M. Grinwis, J.W. Hesselink, J. Kirpensteijn, S.A. van Nimwegen Introduction: Minimally invasive microbrachytherapy is in development to treat solid tumors by intratumoral injection of (radioactive) holmium-166 (166Ho)...
-
Study Protocol: Adjuvant Holmium-166 Radioembolization After Radiofrequency Ablation in Early-Stage Hepatocellular Carcinoma Patients-A Dose-Finding Study (HORA EST HCC Trial)
R.J. Bennink, A.E. Braat, A.S.L.P. Crobach, O.M. van Delden, T. van der Hulle, H.J. Klümpen, R.W. van der Meer, J.F.W. Nijsen, C.S.P. van Rijswijk, J. Roosen, B.N. Ruijter, F. Smit, M.K. Stam, R.B. Takkenberg, M.E. Tushuizen, F.H.P. van Velden, L.F. de...
-
To 1000 Gy and back again: a systematic review on dose-response evaluation in selective internal radiation therapy for primary and secondary liver cancer
J. Roosen, N.J.M. Klaassen, L.E.L. Westlund Gotby, C.G. Overduin, M. Verheij, M.W. Konijnenberg & J.F.W. Nijsen PURPOSE: To systematically review all current evidence into the dose-response relation of yttrium-90 and holmium-166 selective internal...
-
Case Report: Radioactive Holmium-166 Microspheres for the Intratumoral Treatment of a Canine Pituitary Tumor
N.C. Morsink, N.J.M. Klaassen, B.P. Meij, J. Kirpensteijn, G.C.M. Grinwis, I.A. Schaafsma, J.W. Hesselink, J.F.W. Nijsen & S.A. van Nimwegen INTRODUCTION: In this case study, a client-owned dog with a large pituitary tumor was experimentally treated by...
-
Dedicated holmium microsphere administration device for MRI-guided interstitial brain microbrachytherapy
M. de Vries, N.J.M. Klaassen, N.C. Morsink, S.A. van Nimwegen, J.F.W. Nijsen & J.J. van den Dobbelsteen Microbrachytherapy with radioactive holmium-166 (166Ho) microspheres (MS) has the potential to be an effective treatment method for brain...
-
Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
J. Roosen, M.J. Arntz, M.J.R. Janssen, S.F. de Jong, J.J. Fütterer, C.G. Overduin & J.F.W. Nijsen Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic...
-
Quantitative dual-energy CT material decomposition of holmium microspheres: local concentration determination evaluated in phantoms and a rabbit tumor model
R. Gutjahr, R.C. Bakker, F. Tiessens, S.A. van Nimwegen, B. Schmidt & J.F.W. Nijsen OBJECTIVES: The purpose of this study was to assess the feasibility of dual-energy CT-based material decomposition using dual-X-ray spectra information to determine...
-
Characterization of holmium(iii)-acetylacetonate complexes derived from therapeutic microspheres by infrared ion spectroscopy
K.J. Houthuijs, J. Martens, A.G. Arranja, G. Berden, J.F.W. Nijsen & J. Oomens Microspheres containing radioactive 166holmium-acetylacetonate are employed in emerging radionuclide therapies for the treatment of malignancies. At the molecular level,...
-
Feasibility of CT quantification of intratumoural 166 Ho-microspheres
S.A. van Nimwegen, A.D. Barten-van Rijbroek, R.J.J. Van Es, A.J.W.P. Rosenberg, H.W.A.M. de Jong, M.G.E.H. Lam & J.F.W. Nijsen BACKGROUND: Microspheres loaded with radioactive 166Ho (166Ho-MS) are novel particles for radioembolisation and intratumoural...
-
Preparation and characterization of inorganic radioactive holmium-166 microspheres for internal radionuclide therapy
A.G. Arranja, W.E. Hennink, C. Chassagne, A.G. Denkova & J.F.W. Nijsen Microspheres with high specific activities of radionuclides are very interesting for internal radiotherapy treatments. This work focuses on the formulation and characterization of...
-
The various therapeutic applications of the medical isotope holmium-166: a narrative review
N.J.M. Klaassen, M.J. Arntz, A.G. Arranja, J. Roosen & J.F.W. Nijsen Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits...
-
Radioactive holmium phosphate microspheres for cancer treatment
A.G. Arranja, W.E. Hennink, A.G. Denkova, R.W.A. Hendrikx & J.F.W. Nijsen The aim of this study was the development of radioactive holmium phosphate microspheres (HoPO4-MS) with a high holmium content and that are stable in human serum for selective...
-
Efficacy of Radioembolization with 166 Ho-Microspheres in Salvage Patients with Liver Metastases: A Phase 2 Study
J.F. Prince, M.A.A.J. van den Bosch, J.F.W. Nijsen, M.L.J. Smits, A.F. van den Hoven, S. Nikolakopoulos, F.J. Wessels, R.C.G. Bruijnen, M.N.G.J.A. Braat, B.A. Zonnenberg & M.G.E.H. Lam INTRODUCTION: Radioembolization of liver malignancies with...
-
Intratumoral injection of radioactive holmium ( 166 Ho) microspheres for treatment of oral squamous cell carcinoma in cats
S.A. van Nimwegen, R.C. Bakker, J. Kirpensteijn, R.J.J. van Es, R. Koole, M.G.E.H. Lam, J.W. Hesselink & J.F.W. Nijsen BACKGROUND & AIMS: A "microbrachytherapy" was developed as treatment option for inoperable tumours by direct intratumoral injection...
-
Intratumoral injection of radioactive holmium-166 microspheres in recurrent head and neck squamous cell carcinoma: preliminary results of first use
R.C. Bakker, R.J.J. van Es, A.J.W.P. Rosenberg, S.A. van Nimwegen, R. Bastiaannet, H.W.A.M. de Jong, J.F.W. Nijsen & M.G.E.H. Lam BACKGROUND: Limited treatment options exist for patients with locoregional recurrences of head and neck squamous cell...
-
Production of novel diagnostic radionuclides in small medical cyclotrons
M.A. Synowiecki, L.R. Perk & J.F.W. Nijsen The global network of cyclotrons has expanded rapidly over the last decade. The bulk of its industrial potential is composed of small medical cyclotrons with a proton energy below 20 MeV for radionuclides...
-
Intratumoral treatment with radioactive beta-emitting microparticles: a systematic review
R.C. Bakker, M.G.E.H. Lam, S.A. van Nimwegen, A.J.W.P. Rosenberg, R.J.J. van Es & J.F.W. Nijsen PURPOSE: The purpose of this study was to review the role of radioactive microparticles (1-100 μm) for the treatment of solid tumors and provide a...
-
Radioembolization dosimetry: the road ahead
M.L.J. Smits, M. Elschot, D.Y. Sze, Y.H. Kao, J.F.W. Nijsen, A.H. Iagaru, H.W.A.M. de Jong, M.A.A.J. van den Bosch & M.G.E.H. Lam Methods for calculating the activity to be administered during yttrium-90 radioembolization (RE) are largely based on...
-
Alginate Microspheres Containing Temperature Sensitive Liposomes (TSL) for MR-Guided Embolization and Triggered Release of Doxorubicin
M. van Elk, B. Ozbakir, A.D. Barten-Rijbroek, G. Storm, J.F.W. Nijsen, W.E. Hennink, T. Vermonden, & R. Deckers Objective: The objective of this study was to develop and characterize alginate microspheres suitable for embolization with on-demand...