Publications
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Development of an Intratumoral Holmium Microsphere Injection Method in Ex Vivo Human Pancreatic Ductal Adenocarcinoma: A Preclinical Feasibility Study
Martijn Willem Jan Stommel, Cornelis Johannes Henricus Martinus van Laarhoven, Jurgen J Fütterer, Johannes Frank Wilhelmus Nijsen Background/objectives: Patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis. Local therapy...
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The influence of hepatic arterial blood flow rate on holmium microsphere distribution: an MRI study in perfused porcine livers
der Hoek, Jaap G M Greve, H Remco Liefers, Milou Boswinkel, Simon J S Ruiter, Joey Roosen, Erik Groot Jebbink, J Frank W Nijsen Background: Transarterial radioembolisation (TARE) is a treatment for liver malignancies, involving the injection of...
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Lung shunting and radiation pneumonitis after holmium-166 TARE: a case study
W M van Wijk, Marcel J R Janssen, Mark J Arntz, Bram H J Geurts, Laura A Michon, Eric T T L Tjwa, Joey Roosen, J Frank W Nijsen Purpose: The assessment of the lung shunting fraction (LSF) in yttrium-90 (90Y) or holmium-166 (166Ho) transarterial...
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Microspheres in Motion: Investigating the parameters that influence radioembolization
This thesis investigates which parameters influence the distribution of holmium microspheres during transarterial radioembolization (TARE), a treatment for liver tumors. Experiments using 3D-printed models and porcine livers show that catheter...
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Intratumoral Holmium-166 Microsphere Injection in Patients with Unresectable Pancreatic Ductal Adenocarcinoma: A Single-Center, Single-Arm, Open-Label Feasibility and Safety Study
W J Stommel, Marcel J R Janssen, John J Hermans, Harm Westdorp, Cornelis J H M van Laarhoven, Jurgen J Fütterer, J Frank W Nijsen Introduction: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and lacks local treatment options. This study...
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Spatial distribution of fractionally administered holmium microspheres in non-tumorous human liver tissue: how livers survive transarterial radioembolisation
T.J. Snoeijnk, V.E. de Meijer, M. Boswinkel, K.P. de Jong, J. Roosen, A.G. Arranja, J.J. Fütterer, S.J.S. Ruiter, J.F.W. Nijsen Background: Relatively high mean absorbed doses to the non-tumorous liver tissue (NTLT) are generally well tolerated in...
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New podcasts on liver and bile duct tumors, radiobiology, and radioembolization
and advanced treatment techniques. EMERITUS-2: Image-guided radioembolization in primary liver carcinoma Frank Nijsen and Meike van Wijk Listen at Oncologie.nu (link) or on spotify (link). UNRANU: Better understanding of the radiobiology of therapeutic...
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In Vitro Investigation of Microcatheter Behavior During Microsphere Injection in Transarterial Radioembolization
T.J. Snoeijnk, J.L. van der Hoek, H. Mirgolbabaee, T.G. Vlogman, J. Roosen, J.F.W. Nijsen, E. Groot Jebbink Purpose: To experimentally investigate the behavior of a clinically used microcatheter during transarterial radioembolization (TARE) microsphere...
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Jessie Swarts
ablative and transarterial therapies in patients with hepatocellular carcinoma. She is supervised by Jurgen Fütterer, Frank Nijsen, and Kristian Overduin from the Department of Medical Imaging, and Eric Tjwa from the Department of Gastroenterology.
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Development and validation of an innovative administration system to facilitate controlled holmium-166 microsphere administration during TARE
M.W.M. van Wijk, G. van Wolfswinkel, M.J. Arntz, M.J.R. Janssen, J. Roosen, J.F.W. Nijsen Background To develop and validate a novel administration device for holmium-166 transarterial radioembolisation (TARE) with the purpose of facilitating...
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Quantitative CT imaging and radiation-absorbed dose estimations of 166Ho microspheres: paving the way for clinical application
Klaassen, G. van de maat, M. Boswinkel, A. Arranja, R. Bruggink, I. van Houwelingen, I. Schaafsma, J.W. Hesselink, J.F.W. Nijsen, B. van Nimwegen Background Microbrachytherapy enables high local tumor doses sparing surrounding tissues by intratumoral...
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Intraprocedural MRI-based dosimetry during transarterial radioembolization of liver tumours with holmium-166 microspheres (EMERITUS-1): a phase I trial towards adaptive, image-controlled treatment delivery
L.E.L. Westlund Gotby, M.J. Arntz, J.J. Fütterer, M.J.R. Janssen, M.W. Konijnenberg, M.W.M. van Wijk, C.G. Overduin, J.F.W. Nijsen Purpose Transarterial radioembolization (TARE) is a treatment for liver tumours based on injection of radioactive...
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Accuracy of holmium-166 SPECT/CT quantification over a large range of activities
L.E.L. Westlund Gotby, D. Lobeek, J. Roosen, M. de Bakker, M.W. Konijnenberg, J.F.W. Nijsen Background: Quantitative imaging is a crucial step for dosimetry in radionuclide therapies. Traditionally, SPECT/CT imaging is quantified based on...
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Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution
T.J. Snoeijink, T.G. Vlogman, J. Roosen, E. Groot Jebbink, K. Jain, J.F.W. Nijsen Purpose Transarterial radioembolization (TARE) is an established treatment modality for patients with unresectable liver cancer. However, a better understanding of...
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Intratumoral injection therapies for locally advanced pancreatic cancer: systematic review
C.Y. Willink, S.F.M. Jenniskens, NJ.M. Klaassen, M.W.J. Stommel, J.F.W. Nijsen Introduction: Pancreatic cancer has one of the worst prognoses of all cancers. Patients with locally advanced pancreatic cancer have a 12.7-20.2 per cent chance of receiving...
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Chiron Morsink
microspheres, under guidance of co-promotors dr. S.A. van Nimwegen (Faculty of Veterinary Medicine) and dr. J.F.W. Nijsen (Radboudumc), and promotor prof. dr. J.W. Hesselink (Faculty of Veterinary Medicine). The aims of his research are 1) Optimizing...
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MRI-guidance during transarterial radioembolization: towards a personalized treatment approach
Transarterial radioembolization (TARE), also called selective internal radiation therapy (SIRT), is a treatment modality for liver tumours during which radioactive microspheres are injected into (subbranches of) the hepatic artery through a catheter....
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Anne van den Brekel
started her PhD project at the Department of Radiology and Nuclear Medicine of the Radboudumc under supervision of Frank Nijsen and Jurgen Fütterer. Her PhD project is funded by the NWO and focusses on the distribution of radioactive holmium...
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Nienke Klaassen
May 2018, she started her PhD in July 2018 at the Department of Radiology and Nuclear Medicine under supervision of Frank Nijsen and Jurgen Fütterer. The project is funded by the STW and aims to develop an intratumoral treatment using radioactive...
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Joey Roosen
to transarterial radioembolization (TARE) with holmium-166 microspheres, under supervision of Jurgen Fütterer and Frank Nijsen. He defended his thesis in 2022. Currently, he is employed as a radiology resident, and remains connected to the MAGIC group...