Irreversible Electroporation
Irreversible Electroporation (IRE) is a cutting-edge, non-thermal ablation technique used in medical treatments, particularly for targeting tumors in sensitive areas where traditional methods may pose risks. This innovative procedure uses precisely controlled electrical pulses to create microscopic pores in cell membranes, leading to targeted cell death while preserving surrounding structures like blood vessels and nerves.
Our research focus on how to optimize IRE treatment protocols by examining key parameters, including applied voltage, electrode configuration, active needle length, pulse characteristics, and their effects on ablation zone size and thermal risks. Initial findings indicate that higher voltages (≥2000 V), increased electrode count, and extended active needle length correlate with larger ablation zones but may also increase thermal effects. Additionally, we found that partial electrode insulation and active needle length demonstrates the potential to enhance ablation precision while minimizing unintended tissue damage. By refining these parameters, their work contributes to the advancement of IRE as a safer and more effective modality for cancer treatment.
