Challenges in diagnosis, grading and staging of localized prostate cancer

Diederik M. Somford
Promotor J.A. Witjes
Copromotor J.J. Fütterer and I.M. van Oort
Institute Radboud University, Nijmegen, The Netherlands
Date September 26, 2013

The main scope of this thesis is in improving diagnostic algorithms including advanced multiparametric MRI (MP-MRI) techniques to facilitate personalized care for PCa, as it enables more accurate diagnosis, grading and staging of an individual’s PCa. This thesis is comprised of a chapter on increasing the efficacy of PCa diagnosis using prostate biopsy (chapter 3), a chapter on the ability of diffusion-weighted MR imaging (DWI) in grading PCa (chapter 4) and a chapter on risk-stratified staging of PCa by MP-MRI, while also exploring pathological characteristics of the radical prostatectomy (RP) specimen to identify subjects at greatest risk of therapy failure, possibly benefitting from immediate adjuvant therapy (chapter 5).