Publications
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Holmium-lipiodol-alginate microspheres for fluoroscopy-guided embolotherapy and multimodality imaging
C. Oerlemans, P.R. Seevinck, M.L. Smits, W.E. Hennink, C.J.G. Bakker, M.A.A.J. van den Bosch & J.F.W. Nijsen Embolotherapy is a minimally invasive transcatheter technique aiming at reduction or complete obstruction of the blood flow by infusion of...
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Simultaneous R2*, R2, and R2' quantification by combining S0 estimation of the free induction decay with a single spin echo: A single acquisition method for R2 insensitive quantification of holmium-166-loaded microspheres
G.H. van de Maat, H. de Leeuw, P.R. Seevinck, M.A.A.J. van den Bosch, J.F.W. Nijsen & C.J.G. Bakker PURPOSE: To present a new method, S0 estimation of the free induction decay combined with a single spin echo measurement (SOFIDSE), that enables...
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Radiation emission from patients treated with holmium-166 radioembolization
J.F. Prince, M.L.J. Smits, G.C. Krijger, B.A. Zonnenberg, M.A.A.J. van den Bosch, J.F.W. Nijsen & M.G.E.H. Lam PURPOSE: To assess the radiation exposure to individuals coming from patients after treatment with holmium-166 ((166)Ho) microspheres....
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(⁹⁹m)Tc-MAA overestimates the absorbed dose to the lungs in radioembolization: a quantitative evaluation in patients treated with ¹⁶⁶Ho-microspheres
M. Elschot, J.F.W. Nijsen, M.G.E.H. Lam, M.L.J. Smits, J.F. Prince, M.A. Viergever, M.A.A.J. van den Bosch, B.A. Zonnenberg & H.W.A.M. de Jong PURPOSE: Radiation pneumonitis is a rare but serious complication of radioembolic therapy of liver tumours....
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In vivo dosimetry based on SPECT and MR imaging of 166Ho-microspheres for treatment of liver malignancies
A.D. van het Schip, B.A. Zonnenberg, P.R. Seevinck, H.M. Verkooijen, C.J. Bakker, H.W.A.M. de Jong, M.G.E.H. Lam & J.F.W. Nijsen INTRODUCTION: (166)Ho-poly(l-lactic acid) microspheres allow for quantitative imaging with MR imaging or SPECT for...
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Quantitative Monte Carlo-based holmium-166 SPECT reconstruction
M. Elschot, M.L.J. Smits, J.F.W. Nijsen, M.G.E.H. Lam, B.A. Zonnenberg, M.A.A.J. van den Bosch, M.A. Viergever & H.W.A.M. de Jong PURPOSE: Quantitative imaging of the radionuclide distribution is of increasing interest for microsphere radioembolization...
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99mTc-macroaggregated albumin poorly predicts the intrahepatic distribution of 90Y resin microspheres in hepatic radioembolization
M. Wondergem, M.L.J. Smits, M. Elschot, H.W.A.M. de Jong, H.M. Verkooijen, M.A.A.J. van den Bosch, J.F.W. Nijsen & M.G.E.H. Lam INTRODUCTION: In hepatic (90)Y radioembolization, pretreatment (99m)Tc-macroaggregated albumin ((99m)Tc-MAA) nuclear imaging...
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Clinical and laboratory toxicity after intra-arterial radioembolization with (90)y-microspheres for unresectable liver metastases
M.L.J. Smits, A.F. van den Hoven, C.E.N.M. Rosenbaum, B.A. Zonnenberg, M.G.E.H. Lam, J.F.W. Nijsen, M. Koopman & M.A.A.J. van den Bosch OBJECTIVE: To investigate clinical and laboratory toxicity in patients with unresectable liver metastases, treated...
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The necessity of nuclear reactors for targeted radionuclide therapies
G.C. Krijger, B. Ponsard, M. Harfensteller, H.T. Wolterbeek & J.W.F. Nijsen Nuclear medicine has been contributing towards personalized therapies. Nuclear reactors are required for the working horses of both diagnosis and treatment, i.e., Tc-99m and...
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New insights into the HIFU-triggered release from polymeric micelles
R. Deckers, A. Paradissis, C. Oerlemans, M. Talelli, G. Storm, W.E. Hennink & J.F.W. Nijsen Continuous wave (CW), low frequency, high intensity focused ultrasound (HIFU) is a promising modality to trigger release of active compounds from polymeric...
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Intra-arterial radioembolization of breast cancer liver metastases: a structured review
M.L.J. Smits, J.F. Prince, C.E.N.M. Rosenbaum, A.F. van den Hoven, J.F.W. Nijsen, B.A. Zonnenberg, B.A. Seinstra, M.G.E.H. Lam & M.A.A.J. van den Bosch Radioembolization using yttrium-90 microspheres (⁹⁰Y-RE) is an emerging treatment option for breast...
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Microbrachytherapy using holmium-166 acetylacetonate microspheres: a pilot study in a spontaneous cancer animal model
Vandermeulen, I. Gielen, P.R. Seevinck, J. Saunders, A.D. van het Schip, C.J.G. Bakker, G.C. Krijger, K. Peremans & J.F.W. Nijsen PURPOSE: Holmium-166 acetylacetonate microspheres ((166)Ho-AcAc-MS) are proposed as an intratumoral radioablation device....
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MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation
het Schip, M.A.D. Vente, B.A. Zonnenberg, H.W.A.M. de Jong, M.G.E.H. Lam, M.A. Viergever, M.A.A.J. van den Bosch, J.F.W. Nijsen & C.J.G. Bakker OBJECTIVES: To demonstrate the feasibility of MRI-based assessment of the intrahepatic Ho-PLLA-MS...
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Alginate-lanthanide microspheres for MRI-guided embolotherapy
C. Oerlemans, P.R. Seevinck, G.H. van de Maat, H. Boulkhrif, C.J.G. Bakker, W.E. Hennink & J.F.W. Nijsen In cancer therapy, a promising treatment option to accomplish a high tumor-to-normal-tissue ratio is endovascular intervention with microsized...
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Intratumoral administration of holmium-166 acetylacetonate microspheres: antitumor efficacy and feasibility of multimodality imaging in renal cancer
H.W.A.M. de Jong, D.R.A. Uges, J.G.W. Kosterink, P.R. Luijten, W.E. Hennink, A.D. van het Schip, J.L.H.R. Bosch, J.F.W. Nijsen & J.J.M. Jans PURPOSE: The increasing incidence of small renal tumors in an aging population with comorbidities has stimulated...
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The evolution of radioembolisation
M.L.J. Smits, M.A.A.J. van den Bosch, J.F.W. Nijsen & B.A. Zonnenberg No abstract available.
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Transendocardial cell injection is not superior to intracoronary infusion in a porcine model of ischaemic cardiomyopathy: a study on delivery efficiency
T.I.G. van der Spoel, K.R. Vrijsen, S. Koudstaal, J.P.G. Sluijter, J.F.W. Nijsen, H.W. de Jong, I.E. Hoefer, M.M. Cramer, P.A. Doevendans, E. van Belle & S.A.J. Chamuleau Stem cell therapy is a new strategy for chronic ischaemic heart disease in...
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Holmium-166 radioembolisation in patients with unresectable, chemorefractory liver metastases (HEPAR trial): a phase 1, dose-escalation study
M.L.J. Smits, J.F.W. Nijsen, M.A.A.J. van den Bosch, M.G.E.H. Lam, M.A.D. Vente, W.P.T.M. Mali, A.D. van het Schip & B.A. Zonnenberg BACKGROUND: The efficacy of radioembolisation for the treatment of liver tumours depends on the selective distribution...
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Magnetic resonance imaging-based radiation-absorbed dose estimation of 166Ho microspheres in liver radioembolization
P.R. Seevinck, G.H. van de Maat, T.C. de Wit, M.A.D. Vente, J.F.W. Nijsen & C.J.G. Bakker PURPOSE: To investigate the potential of magnetic resonance imaging (MRI) for accurate assessment of the three-dimensional (166)Ho activity distribution to...
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Radioactive holmium acetylacetonate microspheres for interstitial microbrachytherapy: an in vitro and in vivo stability study
Steinebach, M.J. van der Bom, H.Th. Wolterbeek, R.M.A. Heeren, C.J.G. Bakker, A.D. van het Schip, W.E. Hennink & J.F.W. Nijsen PURPOSE: The clinical application of holmium acetylacetonate microspheres (HoAcAcMS) for the intratumoral radionuclide...