Publications
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The bright future of radionuclides for cancer therapy
J.F.W. Nijsen, G.C. Krijger & A.D. van het Schip Originally, nuclear medicine focused on radiopharmaceuticals trapped in organ structures, based on their function, and the presence of disease was seen by the absence of radioactivity. More recently,...
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Imaging and treatment of oncological diseases
J.F.W. Nijsen No abstract available.
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Lanthanide-loaded liposomes for multimodality imaging and therapy
V.A.P. Mateus, C.J.G. Bakker, G.C. Krijger, G. Storm, B.A. Zonnenberg, A.D. van het Schip, G.A. Koning & J.F.W. Nijsen INTRODUCTION: Many advanced molecular imaging agents are currently being investigated preclinically. Especially, liposomes, have...
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Hybrid scatter correction applied to quantitative holmium-166 SPECT
T.C. de Wit, J. Xiao, J.F.W. Nijsen, F.D. van het Schip, S.G. Staelens, P.P. van Rijk & F.J. Beekman Ho-166 is a combined beta-gamma emitter of which the betas can be used therapeutically. From the 81 keV gammas of Ho-166, SPECT images can be obtained,...
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Holmium-loaded poly(L-lactic acid) microspheres: in vitro degradation study
S.W. Zielhuis, J.F.W. Nijsen, G.C. Krijger, A.D. van het Schip & W.E. Hennink The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the...
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Removal of chloroform from biodegradable therapeutic microspheres by radiolysis
S.W. Zielhuis, J.F.W. Nijsen, L. Dorland, G.C. Krijger, A.D. van het Schip & W.E. Hennink Radioactive holmium-166 loaded poly(l-lactic acid) microspheres are promising systems for the treatment of liver malignancies. These microspheres are loaded with...
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Production of GMP-grade radioactive holmium loaded poly(L-lactic acid) microspheres for clinical application
S.W. Zielhuis, J.F.W. Nijsen, R. de Roos, G.C. Krijger, P.P. van Rijk, W.E. Hennink & A.D. van het Schip Radioactive holmium-166 loaded poly(L-lactic acid) microspheres are promising systems for the treatment of liver malignancies. The microspheres are...
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Fully MR-guided hepatic artery catheterization for selective drug delivery: a feasibility study in pigs
J.H. Seppenwoolde, L.W. Bartels, R. van der Weide, J.F.W. Nijsen, A.D. van het Schip & C.J.G. Bakker PURPOSE: To demonstrate the feasibility of hepatic catheterization for selective delivery of therapeutic agents using a clinical MRI scanner for...
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Factors affecting the sensitivity and detection limits of MRI, CT, and SPECT for multimodal diagnostic and therapeutic agents
P.R. Seevinck, J.H. Seppenwoolde, T.C. de Wit, J.F.W. Nijsen, F.J. Beekman, A.D. van het Schip & C.J.G. Bakker Noninvasive imaging techniques like magnetic resonance imaging (MRI), computed tomography (CT) and single photon emission computed tomography...
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Lanthanide bearing microparticulate systems for multi-modality imaging and targeted therapy of cancer
S.W. Zielhuis, J.F.W. Nijsen, J.H. Seppenwoolde, B.A. Zonnenberg, C.J.G. Bakker, W.E. Hennink, P.P. van Rijk & A.D. van het Schip The rapid developments of high-resolution imaging techniques are offering unique possibilities for the guidance and follow...
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Surface characteristics of holmium-loaded poly(L-lactic acid) microspheres
S.W. Zielhuis, J.F.W. Nijsen, R. Figueiredo, B. Feddes, A.M. Vredenberg, A.D. van het Schip & W.E. Hennink Radioactive holmium-166-loaded poly(l-lactic acid) microspheres (Ho-PLLA-MS) are promising systems for the treatment of liver malignancies. The...
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Internal radiation therapy of liver tumors: qualitative and quantitative magnetic resonance imaging of the biodistribution of holmium-loaded microspheres in animal models
J.H. Seppenwoolde, J.F.W. Nijsen, L.W. Bartels, S.W. Zielhuis, A.D. van het Schip & C.J.G. Bakker In internal radiation therapy of unresectable liver tumors, microspheres containing a radionuclide are injected in the hepatic artery to achieve a...
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Liver tumors: MR imaging of radioactive holmium microspheres--phantom and rabbit study
J.F.W. Nijsen, J. Seppenwoolde, T. Havenith, C. Bos, C.J.G. Bakker & A.D. van het Schip PURPOSE: To investigate the use of magnetic resonance (MR) imaging in the administration and biodistribution of holmium-loaded poly(L-lactic acid) microspheres...
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Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres
J.F.W. Nijsen, A.D. van Het Schip, M.J. van Steenbergen, S.W. Zielhuis, L.M.J. Kroon-Batenburg, M. van de Weert, P.P. van Rijk & W.E. Hennink Holmium-loaded microspheres are useful systems in radio-embolization therapy of liver metastases. For...
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Advances in nuclear oncology: microspheres for internal radionuclide therapy of liver tumours
J.F.W. Nijsen, A.D. van het Schip, W.E. Hennink, D.W. Rook, P.P. van Rijk & J.M.H. de Klerk Liver metastases cause the majority of deaths from colorectal cancer, and response to chemotherapy and external radiotherapy is poor. An alternative is internal...
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Holmium-166 poly(l-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model
J.F.W. Nijsen, M.J. van Steenbergen, H. Kooijman, H. Talsma, L.M. Kroon-Batenburg, M. van De Weert, P.P. van Rijk, A. De Witte, A.D. Van Schip & W.E. Hennink Holmium-loaded PLLA microspheres are useful systems in radioembolization therapy of liver...
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Tumour embolization of the Vx2 rabbit head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study
R.J. van Es, J.F.W. Nijsen, H.F. Dullens, M. Kicken, A. van der Bilt, W. Hennink, R. Koole & P.J. Slootweg INTRODUCTION: Intra-arterial embolization of unresectable malignant tumours with biodegradable microspheres is an effective way of selective...
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Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits
R.J. van Es, J.F.W. Nijsen, A.D. van het Schip, H.F. Dullens, P.J. Slootweg & R. Koole A total of 22 NZW rabbits with VX2 squamous cell carcinomas transplanted into the auricles were intra-arterially (i.a.) embolized with radioactive or inactive...
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Targeting of liver tumour in rats by selective delivery of holmium-166 loaded microspheres: a biodistribution study
J.F.W. Nijsen, D. Rook, C. Brandt, R. Meijer, H. Dullens, B. Zonnenberg, J. de Klerk, P. van Rijk, W. Hennink & F. van het Schip Intra-arterial administration of beta-emitting particles that become trapped in the vascular bed of a tumour and remain...
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Diaquatris(pentane-2,4-dionato-O,O′)holmium(III) monohydrate and diaquatris(pentane-2,4-dionato-O,O′)holmium(III) 4-hydroxypentan-2-one solvate dihydrate
H. Kooijman , J.F.W. Nijsen, A.L. Spek & F. van het Schip No abstract available.